TOPLINE:
Older age, male sex, and seropositivity are connected to a greater threat for rheumatoid arthritis– interstitial lung illness (RA-ILD) with a typical interstitial pneumonia (UIP) pattern, while just seropositivity is connected with RA-ILD with a nonspecific interstitial pneumonia pattern (NSIP).
METHOD:
- Scientist carried out a case-control research study utilizing information from 2 associates in the Mass General Brigham Healthcare system to analyze the threat elements related to various subtypes of RA-ILD.
- They recognized 208 clients with RA-ILD (mean age at RA medical diagnosis, 50.7 years; 67.3% females) and 547 control individuals with RA however no ILD (mean age at RA medical diagnosis, 49.1 years; 78.1% ladies), who had actually high-resolution calculated tomography (HRCT) imaging information readily available.
- RA-ILD subtypes such as RA-UIP, RA-NSIP, arranging pneumonia, and others were figured out with HRCT scans.
- The associations in between demographics, way of life, and serologic aspects and RA-ILD subtypes were examined utilizing multivariable logistic regression analysis.
TAKEAWAY:
- The RA-UIP subtype, the one with worst diagnosis, was related to older age throughout the time of RA medical diagnosis (chances ratio [OR]1.03 annually; 95% CI, 1.01-1.05), male sex (OR, 2.15; 95% CI, 1.33-3.48), and seropositivity (OR, 2.08; 95% CI, 1.24-3.48).
- On the other hand, the RA-NSIP subtype was substantially associated just with seropositivity (OR, 3.21; 95% CI, 1.36-7.56).
- Nonfibrotic ILDs were considerably related to favorable cigarette smoking status (OR, 2.81; 95% CI, 1.52-5.21) and seropositivity (OR, 2.09; 95% CI, 1.19-3.67).
- The mix of male sex, seropositivity, and favorable cigarette smoking status was connected with an almost sevenfold increased threat for RA-UIP (OR, 6.89; 95% CI, 2.41-19.69), compared to having no RA-ILD threat elements.
IN PRACTICE:
“These findings recommend that RA-ILD subtypes might have unique danger element profiles and stress the value of more efforts to comprehend RA-ILD illness heterogeneity to notify screening and prognostication techniques,” the authors composed.
SOURCE:
The research study was led by Gregory C. McDermott, MD, MPH, Brigham and Women’s Hospital, Boston, and was released online on September 11, 2024, in Arthritis Care & & Research
CONSTRAINTS:
This research study counted on HRCT imaging, which might have presented choice predisposition within the control groups. RA illness activity steps were not offered for the Mass General Brigham Biobank RA mate, which restricted the analysis of the impact of illness activity on the threat for RA-ILD. Both associates primarily included White clients, which might have restricted the generalizability of the findings to more varied populations.
DISCLOSURES:
Some authors were supported by the Rheumatology Research Foundation Scientist Development Award, a VERITY Pilot & & Feasibility Research Award, the Société Française de Rhumatologie, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and other sources. The authors stated getting grant assistance, seeking advice from costs, and honoraria from numerous companies and pharmaceutical business.
This short article was developed utilizing a number of editorial tools, consisting of AI, as part of the procedure. Human editors examined this material before publication.