Neurology > > Dementia– Study examined diet plan at 3 time points over 10 years
by Judy George, Deputy Managing Editor, MedPage Today December 13, 2024
- Diet plans greater in inflammatory foods were connected to increased dementia threat in older grownups.
- Dangers were greater for both all-cause dementia and Alzheimer’s dementia.
- The research study tracked Dietary Inflammatory Index ratings determined at 3 time points over 10 years.
Diet plans greater in inflammatory foods were connected to an increased occurrence of dementia in older grownups, longitudinal information from the Framingham Heart Study Offspring associate revealed.
Over 13 years of follow-up, greater Dietary Inflammatory Index (DII) ratings balanced throughout 3 time points were linearly connected with an increased occurrence of all-cause dementia (HR 1.21, 95% CI 1.10-1.33, P< 0.001), reported Debora Melo van Lent, PhD, of UT Health San Antonio in Texas, and co-authors.
Greater DII ratings were linearly associated with a boost in Alzheimer’s illness dementia (HR 1.20, 95% CI 1.07-1.34, P=0.002), the scientists reported in Alzheimer’s & & DementiaFindings were changed for group, way of life, and medical covariates.
“Although these appealing findings require to be duplicated and more confirmed, our outcomes recommend that diet plans that associate with low DII ratings might avoid late-life dementia,” van Lent and coworkers kept in mind.
Previous cross-sectional research study from the Framingham Heart Study Offspring accomplice revealed that greater DII ratings– showing more pro-inflammatory foods taken in– associated with smaller sized overall brain and noodle volumes and bigger lateral ventricular volume.
Other associate research studies, consisting of a 3-year research study in Greece, connected diet plans with high inflammatory capacity to an increased danger of event dementia. And scientific trial information revealed the MIND diet plan– a hybrid of the Mediterranean diet plan and the DASH (Dietary Approaches to Stop Hypertension) diet plan that is abundant in anti-inflammatory foods– had a comparable impact on cognition and brain MRI results as moderate calorie constraint over 3 years, potentially due to high adherence of the control group to way of life recommendations.
There’s restricted details about the long-lasting relationship in between diet-driven swelling and event dementia, van Lent and co-authors kept in mind.
The scientists assessed 1,487 individuals in the Framingham Heart Study Offspring research study who were age 60 or older at standard without any widespread dementia. Over half (53%) were ladies, and indicate standard age was 69. About 22% brought an APOE4 allele.
DII ratings were computed utilizing the 126-item Harvard semi-quantitative food frequency survey, which was administered at 3 points over 10 years from 1991 to 2001.
The DII utilized in the analysis included 36 dietary parts consisting of nutrients, entire foods, and caffeine from food consumption. Parts were classified as anti-inflammatory or pro-inflammatory.
Anti-inflammatory elements consisted of alcohol, beta-carotene, caffeine, dietary fiber, folic acid, magnesium, thiamin, riboflavin, niacin, zinc, monounsaturated fat, polyunsaturated fat, omega-3 fat, omega-6 fat, selenium,
