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A brand-new class of prescription antibiotics serves as molecular glue

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  • Research study Highlight
  • Released: 15 February 2024

Microbiology

  • Iris Marchal1

Nature Biotechnology

volume 42, page 184 (2024 )Cite this short article

Gram-negative germs such as Acinetobacter baumannii include lipopolysaccharide (LPS) on their external membrane that obstructs the entry of many small-molecule drugs, that makes the germs hard to eliminate. These prescription antibiotics are typically derivatives of existing classes, and no brand-new classes of prescription antibiotics have actually been established versus these Gram-negative germs for over 50 years. 2 documents in Nature determine and define a brand-new class of prescription antibiotics that targets the LPS transportation equipment, which offers insights into lipid transportation inhibition as a druggable target.

Zampaloni and coworkers determine a class of prescription antibiotics that shows powerful activity versus drug-resistant A. baumannii by carrying out a phenotypic screen of a series of about 45,000 macrocyclic peptides. Following optimization for effectiveness, they establish the medical prospect zosurabalpin, which obstructs LPS transportation from the inner to the external bacterial membrane. Zosurabalpin effectively deals with bacterial infections in a number of mouse designs of infection. Human scientific trials are presently continuous to more establish zosurabalpin as a practical treatment alternative versus drug-resistant A. baumannii

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Author informationAuthors and Affiliations

  1. Nature Biotechnology https://www.nature.com/nbt/

    Iris Marchal

Corresponding author

Correspondence to Iris Marchal.

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Marchal, I. A brand-new class of prescription antibiotics serves as molecular glue.
Nat Biotechnol 42, 184 (2024 ). https://doi.org/10.1038/s41587-024-02145-y

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  • Released: 15 February 2024

  • Concern Date: February 2024

  • DOI: https://doi.org/10.1038/s41587-024-02145-y

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