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Improving flowing growth DNA to enhance liquid biopsies

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  • Research study Highlight
  • Released: 15 February 2024

Cancer

  • Iris Marchal1

Nature Biotechnology

volume 42, page 184 (2024 )Cite this post

Liquid biopsies enable non-invasive growth detection by evaluating distributing growth DNA (ctDNA) in a blood sample. CtDNA in blood is typically sporadic, restricting the level of sensitivity of liquid biopsies. Composing in ScienceMartin-Alonso and associates conquer this obstacle by establishing 2 injectable priming representatives that momentarily increase the concentration of ctDNA in vivo.

To increase the levels of ctDNA in blood circulation, the authors established a nanoparticle that acts upon macrophages in the liver accountable for clearing ctDNA from the blood. The liposomal nanoparticles are effectively phagocytosed by the liver-resident cells, which are then momentarily not able to use up ctDNA. Injecting the nanoparticle guide in mice increased ctDNA healing from blood samples over significantly.

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Author informationAuthors and Affiliations

  1. Nature Biotechnology https://www.nature.com/nbt/

    Iris Marchal

Corresponding author

Correspondence to Iris Marchal.

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Marchal, I. Boosting distributing growth DNA to enhance liquid biopsies.
Nat Biotechnol 42, 184 (2024 ). https://doi.org/10.1038/s41587-024-02154-x

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  • Released: 15 February 2024

  • Problem Date: February 2024

  • DOI: https://doi.org/10.1038/s41587-024-02154-x

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