TBI May Reactivate Herpes Virus Leading to Neurodegeneration
Moderate distressing brain injury (TBI) might reactivate hidden herpes simplex infection type 1 (HSV-1) in the brain and add to neurodegeneration and advancement of Alzheimer's illness (ADVERTISEMENT) pathology, a brand-new research study recommended.Utilizing a three-dimensional (3D) human brain tissue design, scientists observed that quiescent HSV-1 can be reactivated by a mechanical shock simulating concussion, causing signature markers of advertisement, consisting of neuroinflammation and production of amyloid beta and phosphorylated tau (p-tau) and gliosis-- a phenotype worsened by duplicated head injury."This opens the concern regarding whether antiviral drugs or anti-inflammatory representatives may be helpful as early preventive treatments after head injury to stop HSV-1 activation...