Researchers reveal unexpected human vs. mouse distinctions in a significant cancer immunotherapy target
A 3D image reveals a T cell revealing the immune checkpoint receptor PD-1 (green) connecting with an antigen presenting cell revealing the ligand PD-L1 (magenta). Credit: Hui Lab, UC San Diego
Given that its discovery in the 1990s, set cell death protein 1 (PD-1) has actually been considered a leading target in cancer treatments. A checkpoint receptor that frequently lives on the surface area of body immune system cells, the PD-1 particle works as a kind of "off" switch that keeps immune cells from assaulting other cells.
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