Saturday, January 11

Tag: signature markers

TBI May Reactivate Herpes Virus Leading to Neurodegeneration

TBI May Reactivate Herpes Virus Leading to Neurodegeneration

Health and Mediacal
Moderate distressing brain injury (TBI) might reactivate hidden herpes simplex infection type 1 (HSV-1) in the brain and add to neurodegeneration and advancement of Alzheimer's illness (ADVERTISEMENT) pathology, a brand-new research study recommended.Utilizing a three-dimensional (3D) human brain tissue design, scientists observed that quiescent HSV-1 can be reactivated by a mechanical shock simulating concussion, causing signature markers of advertisement, consisting of neuroinflammation and production of amyloid beta and phosphorylated tau (p-tau) and gliosis-- a phenotype worsened by duplicated head injury."This opens the concern regarding whether antiviral drugs or anti-inflammatory representatives may be helpful as early preventive treatments after head injury to stop HSV-1 activation...