Sjögren Subtypes Have Distinct Pathophysiologic Profiles
TOPLINE:Sjögren illness (SjD) provides 3 unique phenotypes-- B-cell active with low sign problem, high systemic activity with high sign problem, and low systemic activity with high sign problem; each phenotype has distinct cytokine profiles and interferon (IFN) signatures, with raised cytokine levels for T and B lymphocyte activation in the very first 2 groups and a popular IFN signature in the B-cell active group.METHOD:Scientist performed this research study to examine whether 3 unique phenotypes of clients with SjD were connected with unique pathophysiological paths and IFN signatures.They consisted of 395 clients (typical age, 53 years; 94% females) from the Assessment of Systemic Signs and Evolution in Sjögren's Syndrome (ASSESS) mate who satisfied the 2002 American-European Consensu...